Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR),...

Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials science, and engineering. This convergence has fostered novel ways of thinking and enabled the development of materials, tools, and technologies that have transformed both basic and applied research, as well as how we address critical societal challenges. In this...

Mutations on genes encoding polycystin-1 (PC1) and -2 (PC2) cause autosomal-dominant polycystic kidney disease. How these two proteins work together to exert anti-cystogenesis remains elusive. PC1 resembles adhesion G-protein coupled receptors and undergoes autocleavage in the extracellular N-terminus to expose a hidden "stalk" region, which is hypothesized to act as a "tethered agonist". Here, we showed that wildtype PC1 and PC2 formed functional heteromeric channel complexes in Xenopus oocytes...

BACKGROUND: Influenza vaccination is widely recommended to prevent death and serious illness in vulnerable people, including those with heart failure. However, the randomised evidence to support this practice is limited and few people are vaccinated in many parts of the world. We aimed to determine whether influenza vaccination can improve the outcome of patients after an episode of acute heart failure requiring admission to hospital in China.

Accurate prognosis prediction is essential for guiding cancer treatment and improving patient outcomes. While recent studies have demonstrated the potential of histopathological images in survival analysis, existing models are typically developed in a cancer-specific manner, lack extensive external validation, and often rely on molecular data that are not routinely available in clinical practice. To address these limitations, we present PROGPATH, a unified model capable of integrating...

The first search for a heavy neutral spin-1 gauge boson (Z^{'}) with nonuniversal fermion couplings produced via vector boson fusion processes and decaying to tau leptons or W bosons is presented. The analysis is performed using LHC data at sqrt[s]=13 TeV, collected from 2016 to 2018 with the CMS experiment and corresponding to an integrated luminosity of 138 fb^{-1}. The data are consistent with the standard model predictions. Upper limits are set on the product of the cross section for...

Symmetry-protected topological phases^(1-4) cannot be described by any local order parameter and are beyond the conventional symmetry-breaking model⁵. They are characterized by topological boundary modes that remain stable under symmetry respecting perturbations^(1-4,6-8). In clean, gapped systems without disorder, the stability of these edge modes is restricted to the zero-temperature manifold; at finite temperatures, interactions with mobile thermal excitations lead to their decay^(9-11). Here...

Atherosclerosis (AS) is a chronic inflammatory disease caused by buildup of plaques in arteries that are made up of lipids. The present study investigated the interventional effects of sea cucumber ultrafine powder (SCUP) prepared by ultrafine grinding on AS by determining the changes in lipid levels, plaque formation, and expression of key proteins in an AS mouse model induced by high-fat feeding. The results showed that ultrafine grinding could effectively increase its polysaccharide release...

CONCLUSIONS: Gateway has been validated as a conversion solution of TAR data to DICOM for Pinnacle versions 7.4f, 8.0d, 8.0m, 9.0, 9.2, 9.8, 9.10, and 16.2.

The inflammatory foreign body response (FBR) following cochlear implantation (CI) can negatively impact CI outcomes, including increased electrode impedances. This study aims to investigate the long-term efficacy of dexamethasone-eluting cochlear implant and locally delivered dexamethasone, a potent anti-inflammatory glucocorticoid, on the intracochlear FBR and electrical impedance post-implantation in a murine model. Preliminary impedance data in humans are also provided as a complement to the...

CONCLUSIONS: Ionocyte-expressed CFTR is required for both chloride absorption and secretion, enabling salt and fluid transport in the large airways.

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive and chemo-resistant sarcomas with poor survival rates. Loss of CDKN2A or P53 following NF1 disruption is a key event in MPNST development. Here, we used CRISPR-Cas9 somatic tumorigenesis in mice to identify transcriptomic and metabolomic features distinguishing CDKN2A- versus P53-deleted MPNSTs. Convergent, multiomic analyses revealed that CDKN2A-deleted MPNSTs are especially dependent on the pentose phosphate pathway (PPP) and...