Glioblastoma (GBM) is the most common and aggressive primary brain cancer in adults. While chemo- and radiotherapy are often effective in treating newly diagnosed GBM, increasing evidence suggests that treatment-induced metabolic alterations promote tumor recurrence and further resistance. In addition, GBM tumors are typically hypoxic, which further contributes to treatment resistance. Recent studies have shown that changes in glioma cell metabolism driven by a shift in the isoform expression of...

CONCLUSION: Lower knee extensor power may be a risk factor for both worsening knee pain severity and the development of frequent knee pain in adults with or at risk for knee OA. Interventions targeting knee extensor power may reduce the risk for incident and progressive knee pain.

A measurement is presented of the cross section in proton-proton collisions for the production of two W bosons and one Z boson. It is based on data recorded by the CMS experiment at the CERN LHC at center-of-mass energies sqrt[s]=13 and 13.6 TeV, corresponding to an integrated luminosity of 200 fb^{-1}. Events with four charged leptons (electrons or muons) in the final state are selected. Both nonresonant WWZ production and ZH production, with the Higgs boson decaying into two W bosons, are...

Bound states of charm and anticharm quarks, known as charmonia, have a rich spectroscopic structure that can be used to probe the dynamics of hadron production in high-energy hadron collisions. Here, the cross section ratio of excited (ψ(2S)) and ground state (J/ψ) vector mesons is measured as a function of the charged-particle multiplicity in proton-lead (pPb) collisions at a center-of-mass (CM) energy per nucleon pair of 8.16 TeV. The data corresponding to an integrated luminosity of 175...

Pharmacological ascorbate (IV delivery, to plasma levels ≈ 15-20 mM) has been shown to be selectively toxic to cancer vs. normal cells as well as inducing radio-chemo-sensitization in non-small cell lung cancer (NSCLC) via increased generation of hydrogen peroxide (H(2)O(2)) and increased intracellular redox-active iron (Fe^(2+)). The current study shows that 24 h pretreatment with an FDA-approved iron-oxide nanoparticle, Ferumoxytol (FMX), enhances the toxicity of P-AscH^(-) in human NSCLC...

Charged hadron elliptic anisotropies (v_{2}) are presented over a wide transverse momentum (p_{T}) range for proton-lead (pPb) and lead-lead (PbPb) collisions at nucleon-nucleon center-of-mass energies of 8.16 and 5.02 TeV, respectively. The data were recorded by the CMS experiment and correspond to integrated luminosities of 186 and 0.607 nb^{-1} for the pPb and PbPb systems, respectively. A four-particle cumulant analysis is performed using subevents separated in pseudorapidity to effectively...

Non-small cell lung cancer (NSCLC) continues to be the number one cause of cancer-related death for both women and men worldwide. More information needs to be gathered to understand the interactions between cancer cells, the immune system, the microenvironment within each tumor, and the host tissue to develop more effective treatment modalities. Reported here is a simple, repeatable method for inducing cancer within the mouse lung, allowing for the monitoring of tumor growth from early to...

High fat diet (HFD)-induced obesity increases the risk and severity of psoriasis. However, the immunoregulatory effects of different HFDs on psoriasis pathogenesis remains poorly understood. Here, mimicking human dietary fat profiles, four HFDs-saturated, monounsaturated, omega-6, and omega-3 fats-were designed and used to induce obesity in mice. Despite comparable obesity levels across groups, only the saturated HFD exacerbated imiquimod (IMQ)-induced psoriasis. This exacerbation correlated...

Obesity is strongly associated with triple-negative breast cancer (TNBC). A better understanding of the molecular mechanisms driving obesity-induced TNBC progression could facilitate development of precision dietary intervention strategies. Here, we used murine models of obesity induced by different high-fat diets (HFDs) to examine their impact on TNBC progression. Compared to a low-fat diet (LFD), both cocoa butter and olive oil HFD induced similar levels of obesity. However, only the olive oil...

Obesity has been associated with non-Hodgkin lymphoma (NHL), but the evidence is inconclusive. We examined the association between genetically determined adiposity and four common NHL subtypes: diffuse large B-cell lymphoma (DLBCL), follicular lymphoma, chronic lymphocytic leukemia, and marginal zone lymphoma, using eight genome-wide association studies of European ancestry (N = 10,629 cases, 9505 controls) and constructing polygenic scores for body mass index (BMI), waist-to-hip ratio (WHR),...

Significant advances in science and engineering often emerge at the intersections of disciplines. Nanoscience and nanotechnology are inherently interdisciplinary, uniting researchers from chemistry, physics, biology, medicine, materials science, and engineering. This convergence has fostered novel ways of thinking and enabled the development of materials, tools, and technologies that have transformed both basic and applied research, as well as how we address critical societal challenges. In this...

Mutations on genes encoding polycystin-1 (PC1) and -2 (PC2) cause autosomal-dominant polycystic kidney disease. How these two proteins work together to exert anti-cystogenesis remains elusive. PC1 resembles adhesion G-protein coupled receptors and undergoes autocleavage in the extracellular N-terminus to expose a hidden "stalk" region, which is hypothesized to act as a "tethered agonist". Here, we showed that wildtype PC1 and PC2 formed functional heteromeric channel complexes in Xenopus oocytes...