Detecting photon echoes from superconducting Higgs modes is challenging due to the necessity of preserving and retrieving phase coherence encoded in multiple Higgs and quasiparticle (QP) excitations. Here, we demonstrate the emergence of a Higgs echo in niobium superconductors. This approach disentangles unique quantum pathways involving the Higgs mode and QP excitations. Using Higgs echo spectroscopy, we also uncover unconventional echo formation caused by inhomogeneous broadening and "soft" QP...

CONCLUSION: The proposed T1-weighted cine MRI sequence can produce quality T1-weighted images capable of tracking tumor motion over time. This demonstrates the sequence's potential in motion monitoring tasks as an alternative to the bTFE sequence when necessary.

Colletotrichum fungi cause destructive diseases among a wide range of hosts worldwide. We found that effector CfEC92 from C. fructicola specifically binds ATP through an unidentified ATP-binding domain, leading to changes in the protein secondary structure. The residues Cys^(26), Asn^(38), and Cys^(39) were critical for ATP binding with CfEC92, and mutations at these sites impaired the ability to suppress host immunity. CfEC92 interacted with MdNDPK2, a negative immune regulator in apple. The...

While numerous meta-analyses, reviews, and task forces from various scientific bodies have linked violent media use to aggression, some studies report null effects and claim that such a relationship is non-existent. Several scholars have noted that potential methodological and statistical errors could explain failures to replicate these effects. One recent failure to replicate established violent video game effects (Przybylski and Weinstein 2019) has made its data set publicly available, thereby...

Breast cancer patients with diminished xanthine oxidoreductase (XOR) expression have a greater risk for metastases and diminished survival; however, the mechanisms underpinning this phenomenon are unknown. Under normal growth conditions, neither triple negative MDA-MB-231 nor ER-positive MCF-7 cells demonstrated detectable expression of XOR mRNA, protein and enzymatic activity, which was confirmed using archived in silico data. Enforced expression of XOR did not yield viable cells with...

Regulatory elements are essential components of plant genomes that have shaped the domestication and improvement of modern crops. However, their identity, function and diversity remain poorly characterized, limiting our ability to harness their full power for agricultural advances using induced or natural variation. Here we mapped transcription factor (TF) binding for 200 TFs from 30 families in two distinct maize inbred lines historically used in maize breeding. TF binding comparison revealed...

To maintain potassium homeostasis, the kidney's distal convoluted tubule (DCT) evolved to convert small changes in blood [K+] into robust effects on salt reabsorption. This process requires NaCl cotransporter (NCC) activation by the With-No-Lysine (WNK) kinases. During hypokalemia, the Kidney-Specific WNK1 isoform (KS-WNK1) scaffolds the DCT-expressed WNK signaling pathway within biomolecular condensates of unknown function termed WNK bodies. Here, we show that KS-WNK1 amplifies kidney tubule...

Glioblastoma multiforme (GBM) is the most aggressive and lethal malignant brain tumor, with limited treatment options and poor patient prognosis. Novel therapeutic strategies are urgently needed to extend survival and improve quality of life for GBM patients. Our transcriptomic analysis revealed that GBM cells exhibit substantial upregulation of DNA damage response (DDR) pathways, identifying DDR as a promising therapeutic target. To leverage this vulnerability, we investigated pharmacological...

This Letter reports the precise measurement of the reactor antineutrino spectrum and flux based on the full dataset of 4.7×10^{6} inverse-beta-decay candidates collected at Daya Bay near detectors. Expressed in terms of the inverse-beta-decay yield per fission, the antineutrino spectra from all reactor fissile isotopes and the specific ^{235}U and ^{239}Pu isotopes are measured with 1.3%, 3%, and 8% uncertainties, respectively, near the 3 MeV spectrum peak in reconstructed energy, reaching the...

Gallium based therapeutic strategies are thought to be an effective means to promote tumor cell killing that are currently being investigated in glioblastoma. Gallium is a group IIIa metal that is redox inactive, however, its atomic similarity to iron allows it to serve as an iron mimic that may disrupt Fe metabolism. The current understanding of its mechanism of action is related to its ability to inhibit ribonucleotide reductase and the electron transport chain, however, its effects on other...

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Pharmacological ascorbate (P-AscH, high-dose, intravenous, vitamin C), is a pro-drug that generates hydrogen peroxide (H(2)O(2)) and is being investigated as a neoadjuvant treatment for pancreatic adenocarcinoma (PDAC). In a randomized, phase II clinical trial, P-AscH demonstrated encouraging results in terms of efficacy and safety. However, some patients do not respond to P-AscH suggesting that resistance occurs in a subset of patients. The aims of this study were two-fold: first to...