Publications

Mucosal microbiome markers of complete pathologic response to neoadjuvant therapy in rectal carcinoma

Tuesday, April 22, 2025
Ibrahim M Abukhiran
The intestinal microbiome contributes to colorectal carcinogenesis, disease progression, and response to therapy. Pathologic complete response is the therapeutic goal of neoadjuvant chemoradiation in rectal carcinoma. Nonoperative management has become an accepted strategy, and markers of complete treatment response are needed. Intestinal commensal bacteria contribute to treatment response and radiation colitis, and microbiome-targeted therapies have shown promise in clinical trials. We...

Search for Fractionally Charged Particles in Proton-Proton Collisions at sqrt[s]=13  TeV

Friday, April 18, 2025
A Hayrapetyan
A search is presented for fractionally charged particles with charges below 1e, using their small energy loss in the tracking detector as a key variable to observe a signal. The analyzed dataset corresponds to an integrated luminosity of 138 fb^{-1} of proton-proton collisions collected at sqrt[s]=13 TeV in 2016-2018 at the CERN LHC. This is the first search at the LHC for new particles with a charge between e/3 and 0.9e, including an extension of previous results at a charge of 2e/3. Masses up...

Improved Survival and Prognostication in Melanoma Patients With Brain Metastases: An Update of the Melanoma Graded Prognostic Assessment

Thursday, April 17, 2025
Paul W Sperduto
CONCLUSION: Prognostic factors have changed and survival has improved for patients with MBM but varies widely by GPA. The updated Melanoma GPA calculator (BrainMetGPA), available free online, can be used to estimate survival, individualize treatment, stratify clinical trials, guide surveillance, and augment clinical trial eligibility. Multidisciplinary treatment is essential. Trials are needed to elucidate the optimal sequencing of various therapeutic modalities.

Pathogenomic fingerprinting to identify associations between tumor morphology and epigenetic states

Wednesday, April 16, 2025
Shayan Monabbati
CONCLUSION: This computational approach is the first to assess the correlation between pathomic and epigenetic features in the context of cancer.

A review of periostin in orthopedics

Friday, April 11, 2025
Mark D Wishman
CONCLUSIONS: POSTN is pivotal in musculoskeletal development, fracture healing and bone biology, offering potential as a prognostic biomarker for orthopedic conditions and a tool for monitoring disease progression. Its significant role in PTOA development suggests that targeting POSTN and its downstream inflammatory mediators offer innovative strategies for managing PTOA, warranting further research and clinical exploration.

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector

Friday, April 11, 2025
G Aad
A search is performed for dark matter particles produced in association with a resonantly produced pair of b-quarks with 30

Hyperactivated YAP1 is essential for sustainable progression of renal clear cell carcinoma

Thursday, April 10, 2025
Xiangmin Lv
The most notable progress in renal clear cell carcinoma (ccRCC) in the past decades is the introduction of drugs targeting the VHL-HIF signaling pathway-associated angiogenesis. However, mechanisms underlying the development of VHL mutation-independent ccRCC are unclear. Here we provide evidence that the disrupted Hippo-YAP signaling contributes to the development of ccRCC independent of VHL alteration. We found that YAP1 and its primary target genes are frequently upregulated in ccRCC and the...

Search for Nuclear Modifications of B^{+} Meson Production in p-Pb Collisions at sqrt[s_{NN}]=8.16  TeV

Monday, April 7, 2025
A Hayrapetyan
Nuclear medium effects on B^{+} meson production are studied using the binary-collision scaled cross section ratio between events of different charged-particle multiplicities from proton-lead collisions. Data, collected by the CMS experiment in 2016 at a nucleon-nucleon center-of-mass energy of sqrt[s_{NN}]=8.16 TeV, corresponding to an integrated luminosity of 175 nb^{-1}, were used. The scaling factors in the ratio are determined using a novel approach based on the Z→μ^{-}μ^{+} cross sections...

Observation of the magnonic Dicke superradiant phase transition

Friday, April 4, 2025
Dasom Kim
Two-level atoms ultrastrongly coupled with single-mode cavity photons are predicted to exhibit a quantum phase transition, entering a phase in which both the atomic polarization and the photonic field are finite even without external driving. However, this phenomenon, the superradiant phase transition (SRPT), is forbidden by a no-go theorem due to the existence of the diamagnetic term. Here, we present spectroscopic evidence for a magnonic SRPT in ErFeO(3), where the role of the photonic mode...

Artificial intelligence-based virtual staining platform for identifying tumor-associated macrophages from hematoxylin and eosin-stained images

Sunday, March 30, 2025
Arpit Aggarwal
CONCLUSION: These findings establish VISTA as a computational platform for generating virtual IHC and facilitating the discovery of novel biomarkers from H&E images.

Targeting the disrupted Hippo signaling to prevent neoplastic renal epithelial cell immune evasion

Tuesday, March 25, 2025
Xiangmin Lv
Large-scale cancer genetic/genomic studies demonstrated that papillary renal cell carcinoma (pRCC) is featured with a frequent shallow deletion of the upstream tumor suppressors of the Hippo/YAP signaling pathway, suggesting that this signaling pathway may play a role in pRCC development. Here we develop a transgenic mouse model with a renal epithelial cell-specific hyperactivation of YAP1 and find that hyperactivation of YAP1 can induce dedifferentiation and transformation of renal tubular...

Deep learning informed multimodal fusion of radiology and pathology to predict outcomes in HPV-associated oropharyngeal squamous cell carcinoma

Sunday, March 23, 2025
Bolin Song
BACKGROUND: We aim to predict outcomes of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), a subtype of head and neck cancer characterized with improved clinical outcome and better response to therapy. Pathology and radiology focused AI-based prognostic models have been independently developed for OPSCC, but their integration incorporating both primary tumour (PT) and metastatic cervical lymph node (LN) remains unexamined.