[This corrects the article DOI: 10.3389/fonc.2025.1575001.].

CONCLUSION: The DRIFT enables controlled sequential delivery of Gem/Doce, reliably maintaining docetaxel containment for up to 120 min during gemcitabine pre-treatment. Future in vivo validation will establish safety and therapeutic potential. This platform has broader applications beyond NMIBC, including urinary tract infections and interstitial cystitis.

Glioblastoma multiforme (GBM) is an aggressive brain tumor with limited treatment options and a poor prognosis. Natural phytochemicals from Dendrobium species, particularly bibenzyl derivatives, possess diverse pharmacological activities, yet their potential against GBM remains largely unexplored. Here, we investigated the anticancer activity of 4,5,4'-trihydroxy-3,3'-dimethoxybibenzyl (TDB), a potent antioxidant bibenzyl derivative isolated from Dendrobium pachyglossum. In U87MG cells, TDB...

A search for the rare decay D^{0}→μ^{+}μ^{-} is reported using proton-proton collision events at sqrt[s]=13.6 TeV collected by the CMS detector in 2022-2023, corresponding to an integrated luminosity of 64.5 fb^{-1}. This is the first analysis to use a newly developed inclusive dimuon trigger, expanding the scope of the CMS flavor physics program. The search uses D^{0} mesons obtained from D^{*+}→D^{0}π^{+} decays. No significant excess is observed. A limit on the branching fraction of...

CONCLUSIONS: Biomarkers of impaired distal perfusion, anterior circulation borderzone infarct, and hypoperfusion mismatch were associated with increased risk of recurrent ischemic stroke. These findings support the use of perfusion imaging in ICAS as well as future trials investigating early reperfusion in high-risk patients with ICAS.

Phytopathogenic fungi secrete a great number of effector proteins into various organelles of host plants and suppress plant immunity through different mechanisms. In this study, we identify SCRE7 as a unique nuclear effector that is essential for U. virens infection. SCRE7 interacts with a transcription factor OsLBD11/12 in rice nuclei. Interestingly, defence responses and rice resistance against bacterial and fungal diseases are negatively modulated by SCRE7, but positively regulated by...

The polarization of the Λ and Λ[over ¯] hyperons along the beam direction has been measured in proton-lead (p-Pb) collisions at a center-of-mass energy per nucleon pair of 8.16 TeV. The data were obtained with the CMS detector at the LHC and correspond to an integrated luminosity of 186.0±6.5 nb^{-1}. A significant azimuthal dependence of the hyperon polarization, characterized by the second-order Fourier sine coefficient P_{z,s2}, is observed. The P_{z,s2} values decrease as a function of...

Melanized fungi are known for their remarkable resilience to environmental stress, largely attributed to the protective properties of melanin. In this study, we establish the black yeast Exophiala viscosa as a non-pathogenic, genetically tractable model for the scalable production and functional analysis of DHN-melanin (allomelanin). Cultivation in flasks and bioreactors yielded up to 8.6 g/L of melanin, with the majority tightly incorporated into the cell wall as "melanin ghosts". Chemical...

BACKGROUND AND OBJECTIVES: Retinal optical coherence tomography (OCT) in rodent models has been used to longitudinally image retinal changes, to define end points for more costly or time-consuming experiments, and to better understand the pathophysiology underlying OCT findings in human diseases. No standardization of rodent OCT reporting currently exists. Here, we aim to establish consensus recommendation for reporting results from retinal OCT studies in rodents.

Cancer cachexia, a multifactorial condition resulting in muscle and adipose tissue wasting, reduces the quality of life of many people with cancer. Cachexia is highly prevalent in people with pancreatic ductal adenocarcinoma (PDAC), and many animal models of pancreatic cancer are used to understand the mechanisms underlying cachexia. One such model is the Kras^(LSL-G12D), Ptf1a^(Cre-ER/+), Pten^(flox/flox) (KPP) model, which utilizes an inducible Cre recombinase to initiate tumor development by...

This Letter reports the first evidence of electroweak production of same-sign W boson pairs where at least one of the W bosons is longitudinally polarized and the most stringent constraint to date for the production of two longitudinally polarized same-sign W bosons. The dataset used corresponds to an integrated luminosity of 140 fb^{-1} of proton-proton collisions at a center-of-mass energy of 13 TeV, collected with the ATLAS detector during run 2 of the Large Hadron Collider. The study is...

Incoherent J/ψ photoproduction in heavy ion ultraperipheral collisions (UPCs) provides a sensitive probe of localized, fluctuating gluonic structures within heavy nuclei. This Letter reports the first measurement of the photon-nucleon center-of-mass energy (W_{γN}) dependence of this process in PbPb UPCs at a nucleon-nucleon center-of-mass energy of 5.02 TeV, using 1.52 nb^{-1} of data recorded by the CMS experiment. The measurement covers a wide W_{γN} range of ≈40-400 GeV, probing gluons...