The intestinal microbiome contributes to colorectal carcinogenesis, disease progression, and response to therapy. Pathologic complete response is the therapeutic goal of neoadjuvant chemoradiation in rectal carcinoma. Nonoperative management has become an accepted strategy, and markers of complete treatment response are needed. Intestinal commensal bacteria contribute to treatment response and radiation colitis, and microbiome-targeted therapies have shown promise in clinical trials. We...

A search is presented for fractionally charged particles with charges below 1e, using their small energy loss in the tracking detector as a key variable to observe a signal. The analyzed dataset corresponds to an integrated luminosity of 138 fb^{-1} of proton-proton collisions collected at sqrt[s]=13 TeV in 2016-2018 at the CERN LHC. This is the first search at the LHC for new particles with a charge between e/3 and 0.9e, including an extension of previous results at a charge of 2e/3. Masses up...

CONCLUSION: Prognostic factors have changed and survival has improved for patients with MBM but varies widely by GPA. The updated Melanoma GPA calculator (BrainMetGPA), available free online, can be used to estimate survival, individualize treatment, stratify clinical trials, guide surveillance, and augment clinical trial eligibility. Multidisciplinary treatment is essential. Trials are needed to elucidate the optimal sequencing of various therapeutic modalities.

CONCLUSION: This computational approach is the first to assess the correlation between pathomic and epigenetic features in the context of cancer.

CONCLUSIONS: POSTN is pivotal in musculoskeletal development, fracture healing and bone biology, offering potential as a prognostic biomarker for orthopedic conditions and a tool for monitoring disease progression. Its significant role in PTOA development suggests that targeting POSTN and its downstream inflammatory mediators offer innovative strategies for managing PTOA, warranting further research and clinical exploration.

A search is performed for dark matter particles produced in association with a resonantly produced pair of b-quarks with 30

The most notable progress in renal clear cell carcinoma (ccRCC) in the past decades is the introduction of drugs targeting the VHL-HIF signaling pathway-associated angiogenesis. However, mechanisms underlying the development of VHL mutation-independent ccRCC are unclear. Here we provide evidence that the disrupted Hippo-YAP signaling contributes to the development of ccRCC independent of VHL alteration. We found that YAP1 and its primary target genes are frequently upregulated in ccRCC and the...

Nuclear medium effects on B^{+} meson production are studied using the binary-collision scaled cross section ratio between events of different charged-particle multiplicities from proton-lead collisions. Data, collected by the CMS experiment in 2016 at a nucleon-nucleon center-of-mass energy of sqrt[s_{NN}]=8.16 TeV, corresponding to an integrated luminosity of 175 nb^{-1}, were used. The scaling factors in the ratio are determined using a novel approach based on the Z→μ^{-}μ^{+} cross sections...

Two-level atoms ultrastrongly coupled with single-mode cavity photons are predicted to exhibit a quantum phase transition, entering a phase in which both the atomic polarization and the photonic field are finite even without external driving. However, this phenomenon, the superradiant phase transition (SRPT), is forbidden by a no-go theorem due to the existence of the diamagnetic term. Here, we present spectroscopic evidence for a magnonic SRPT in ErFeO(3), where the role of the photonic mode...

CONCLUSION: These findings establish VISTA as a computational platform for generating virtual IHC and facilitating the discovery of novel biomarkers from H&E images.

Large-scale cancer genetic/genomic studies demonstrated that papillary renal cell carcinoma (pRCC) is featured with a frequent shallow deletion of the upstream tumor suppressors of the Hippo/YAP signaling pathway, suggesting that this signaling pathway may play a role in pRCC development. Here we develop a transgenic mouse model with a renal epithelial cell-specific hyperactivation of YAP1 and find that hyperactivation of YAP1 can induce dedifferentiation and transformation of renal tubular...

BACKGROUND: We aim to predict outcomes of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), a subtype of head and neck cancer characterized with improved clinical outcome and better response to therapy. Pathology and radiology focused AI-based prognostic models have been independently developed for OPSCC, but their integration incorporating both primary tumour (PT) and metastatic cervical lymph node (LN) remains unexamined.